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What does science say about the relationship between cannabinoids and Alzheimer's?
Studies suggest that the major cannabinoids found in hemp reduce plaque and tangle build-up, and therefore show viable potential as complementary treatment options for Alzheimer's disease. The possible efficacy of cannabis for Alzheimer's disease has been linked to its interaction with the endocannabinoid system, which modulates various pathological processes associated with neurodegenerative disorders, including neuroinflammation, excitotoxicity, mitochondrial dysfunction, and oxidative stress. CB1 receptors of the endocannabinoid system have been shown to regulate neurotransmitters involved in excitotoxic neurodegenerative processes, while CB2 receptors have been shown to reduce inflammation associated with Alzheimer's disease.
The use of cannabinoids has been shown to be effective in reducing beta-amyloid levels and improving mitochondrial function, leading the researchers to conclude that "complementary therapy with cannabinoids could be a potential therapeutic option for Alzheimer's through multiple functions and pathways. " A previous study also found that various cannabinoid compounds are effective in preventing beta amyloid aggregation, indicating that it could affect disease progression. Another study showed that cannabinoid therapy can reduce night motor activity and agitation in patients with dementia, suggesting that it may be also beneficial in treating behavioral and circadian disorders.
Lack of glucose uptake has been linked to a worsening of brain diseases such as Alzheimer's disease, and findings in an animal trial suggest that prolonged use of cannabionoids may promote increased glucose uptake in the brain, and that hemp-derived cannabinoid compounds could be beneficial in treating Alzheimer's disease through multiple methods.
Cannabinoids provide a multifaceted approach to the treatment of Alzheimer's that undoubtedly must be thoroughly studied to find its true use, but today the horizon is full of high hopes.
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